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Inhibition of heat shock protein 90 with AUY922 represses tumor growth in a transgenic mouse model of islet cell neoplasms

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Fendrich, Volker ; Wichmann, Sven ; Wiese, Dominik ; Waldmann, Jens ; Lauth, Matthias ; Rexin, P. ; Lopez, C. L. ; Schlitt, Hans J. ; Bartsch, D. ; Lang, Sven A.
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Date of publication of this fulltext: 02 Oct 2019 13:12


Background: This study was designed to evaluate the role of heat shock protein 90 (HSP90) in tumor progression of murine islet cell tumors. Blockade of HSP90 has recently been proposed as a therapeutic target, but effects in models of islet cell tumors with AUY922, a newly developed HSP90 inhibitor, have not been examined. Material and Methods: The carcinoid cell line BON-1 and the HSP90 ...


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