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Mdm2 SNP309 G-Variant Is Associated with Invasive Growth of Human Urinary Bladder Cancer

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Hitzenbichler, F. ; Stoehr, C. G. ; Rogenhofer, M. ; Ruemmele, P. ; Hartmann, A. ; Stoehr, Robert
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Date of publication of this fulltext: 09 Oct 2019 11:19


Objective: Human mouse double minute 2 (Mdm2) is essential in degrading p53 by acting as an ubiquitin ligase and therefore plays a vital role in cell cycle and survival. The G-variant of the Mdm2 SNP309, which is located within the promoter of the Mdm2 gene, increases expression of Mdm2 and thereby inhibits the p53 pathway. Several studies have investigated the influence of this SNP on disease ...


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