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Hypoxia Induces the Expression of Transketolase-Like 1 in Human Colorectal Cancer

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Bentz, S. ; Cee, A. ; Endlicher, E.
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Date of publication of this fulltext: 10 Oct 2019 07:11


Background and Aims: Transketolase-like (TKTL) 1 is one of the key enzymes for anaerobic sugar degradation even in the presence of oxygen (aerobic glycolysis). Transketolase-dependent reactions supply malignant tumors with ribose and NADPH. Therefore, TKTL1 activity could be crucial for tumor proliferation and survival. The aim of the study was to evaluate the expression of TKTL1 in colorectal ...


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