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Bronchoepithelial Expression of CXCR1 and CXCR2 Does Not Facilitate Transepithelial Migration of Neutrophils

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Schulz, Christian ; Stoelcker, Benjamin ; Ruhland, Brigitte ; Jentsch, Nico ; Steege, Andreas
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Date of publication of this fulltext: 23 Oct 2019 09:46


Background: Neutrophilic airway inflammation is one of the key features of chronic obstructive pulmonary disease (COPD). The chemokine receptors 1 (CXCR1) and 2 (CXCR2) are expressed in the bronchial mucosa during chronic inflammation and might be of importance for transepithelial migration of neutrophils. Objectives: This study addressed the role of bronchoepithelial CXCR1 and CXCR2 expression ...


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