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MIP-3α Expression in Macrophages Is NOD Dependent

Hausmann, Martin, Zeitler, C., Weber, A., Krebs, M., Kellermeier, S., Rosenstiel, P., de Vallière, C., Kosovac, K., Fried, M., Holler, Ernst and Rogler, G. (2012) MIP-3α Expression in Macrophages Is NOD Dependent. Digestion 85, pp. 192-201.

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Date of publication of this fulltext: 23 Oct 2019 10:29

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Other URL: https://www.karger.com/Article/FullText/335423


Background: The first identified susceptibility gene for Crohn’s disease, NOD2, acts as a sensor for the bacterial-wall peptidoglycan fragment muramyl dipeptide (MDP) and activates the transcription factor nuclear factor-ĸB (NF-ĸB). Upon NF-ĸB activation, intestinal macrophages (IMACs) induce expression of macrophage inflammatory protein (MIP)-3α to attract memory T lymphocytes. We therefore ...


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Item type:Article
Additional Information (public):OA-Komponente aus Allianzlizenz
Institutions:Medicine > Lehrstuhl für Innere Medizin I
Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie)
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Keywords:Monocytes/macrophages, NOD2/CARD15, MIP-3α expression, Inflammatory bowel disease
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:40894
Owner only: item control page


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