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MIP-3α Expression in Macrophages Is NOD Dependent

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Hausmann, Martin ; Zeitler, C. ; Weber, A. ; Krebs, M. ; Kellermeier, S. ; Rosenstiel, P. ; de Vallière, C. ; Kosovac, K. ; Fried, M. ; Holler, Ernst ; Rogler, G.
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Date of publication of this fulltext: 23 Oct 2019 10:29


Background: The first identified susceptibility gene for Crohn’s disease, NOD2, acts as a sensor for the bacterial-wall peptidoglycan fragment muramyl dipeptide (MDP) and activates the transcription factor nuclear factor-ĸB (NF-ĸB). Upon NF-ĸB activation, intestinal macrophages (IMACs) induce expression of macrophage inflammatory protein (MIP)-3α to attract memory T lymphocytes. We therefore ...


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