MIP-3α Expression in Macrophages Is NOD Dependent

URN to cite this document:: urn:nbn:de:bvb:355-epub-408947
DOI to cite this document:: 10.5283/epub.40894

Hausmann, Martin ; Zeitler, C. ; Weber, A. ; Krebs, M. ; Kellermeier, S. ; Rosenstiel, P. ; de Vallière, C. ; Kosovac, K. ; Fried, M. ; Holler, Ernst ; Rogler, G.

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Date of publication of this fulltext: 23 Oct 2019 10:29

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Abstract

Background: The first identified susceptibility gene for Crohn’s disease, NOD2, acts as a sensor for the bacterial-wall peptidoglycan fragment muramyl dipeptide (MDP) and activates the transcription factor nuclear factor-ĸB (NF-ĸB). Upon NF-ĸB activation, intestinal macrophages (IMACs) induce expression of macrophage inflammatory protein (MIP)-3α to attract memory T lymphocytes. We therefore ...