Inhibition of Collagen XVI Expression Reduces Glioma Cell Invasiveness

URN to cite this document:: urn:nbn:de:bvb:355-epub-409017
DOI to cite this document:: 10.5283/epub.40901

Bauer, Richard ; Ratzinger, Sabine ; Wales, Lynn ; Bosserhoff, Anja

; Senner, V. ; Grifka, Joachim ; Grässel, Susanne

Preview

PDF - Published Version
(632kB)

Date of publication of this fulltext: 24 Oct 2019 11:39

Alternative links to fulltext:DOI Publisher

Details

Preview

Indexed in

Export bibliographical data

Abstract

Glioblastomas are characterized by an intense local invasiveness that limits surgical resection. One mechanism by which glioma cells enforce their migration into brain tissue is reorganization of tumour associated extracellular matrix (ECM). Collagen XVI is a minor component of connective tissues. However, in glioblastoma tissue it is dramatically upregulated compared to the ECM of normal cortex. ...