Knock-Out of beta-Glucosidase 2 Has No Influence on Dextran Sulfate Sodium-Induced Colitis

URN to cite this document:: urn:nbn:de:bvb:355-epub-409028

Scharl, M. ; Leucht, K. ; Frey-Wagner, I. ; Zeitz, J. ; Hausmann, M. ; Fischbeck, A. ; Liebisch, Gerhard

; Schmitz, Gerd

; Rogler, Gerhard

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Date of publication of this fulltext: 24 Oct 2019 11:48

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Abstract

Background/Aims: The non-lysosomal glucosylceramidase, β-glucosidase (Gba2), hydrolyzes glucosylceramide to glucose and ceramide (Cer). Cer is a potent second-messenger lipid that plays an important role in signaling cascades involved in apoptosis. The aim of this study was to investigate whether Gba2 knock-out (Gba2–/–) affects the extent of dextran sulfate sodium (DSS)-induced colitis in mice. ...