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Knock-Out of beta-Glucosidase 2 Has No Influence on Dextran Sulfate Sodium-Induced Colitis

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Scharl, M. ; Leucht, K. ; Frey-Wagner, I. ; Zeitz, J. ; Hausmann, M. ; Fischbeck, A. ; Liebisch, Gerhard ; Schmitz, Gerd ; Rogler, Gerhard
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Date of publication of this fulltext: 24 Oct 2019 11:48


Background/Aims: The non-lysosomal glucosylceramidase, β-glucosidase (Gba2), hydrolyzes glucosylceramide to glucose and ceramide (Cer). Cer is a potent second-messenger lipid that plays an important role in signaling cascades involved in apoptosis. The aim of this study was to investigate whether Gba2 knock-out (Gba2–/–) affects the extent of dextran sulfate sodium (DSS)-induced colitis in mice. ...


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