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Knock-Out of beta-Glucosidase 2 Has No Influence on Dextran Sulfate Sodium-Induced Colitis
Scharl, M., Leucht, K., Frey-Wagner, I., Zeitz, J., Hausmann, M., Fischbeck, A., Liebisch, Gerhard
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(2011)
Knock-Out of beta-Glucosidase 2 Has No Influence on Dextran Sulfate Sodium-Induced Colitis.
Digestion 84, pp. 156-167.
Date of publication of this fulltext: 24 Oct 2019 11:48
Article
DOI to cite this document: 10.5283/epub.40902
Abstract
Background/Aims: The non-lysosomal glucosylceramidase, beta-glucosidase (Gba2), hydrolyzes glucosylceramide to glucose and ceramide (Cer). Cer is a potent second-messenger lipid that plays an important role in signaling cascades involved in apoptosis. The aim of this study was to investigate whether Gba2 knock-out (Gba2(-/-)) affects the extent of dextran sulfate sodium (DSS)-induced colitis in ...
Background/Aims: The non-lysosomal glucosylceramidase, beta-glucosidase (Gba2), hydrolyzes glucosylceramide to glucose and ceramide (Cer). Cer is a potent second-messenger lipid that plays an important role in signaling cascades involved in apoptosis. The aim of this study was to investigate whether Gba2 knock-out (Gba2(-/-)) affects the extent of dextran sulfate sodium (DSS)-induced colitis in mice. Methods: Acute colitis was induced in wild-type (WT) and Gba2(-/-) mice by administration of 2% DSS in drinking water. After 7 days, mice underwent colonoscopy and were sacrificed. Results: Both DSS-treated WT (n = 10) and Gba2(-/-) (n = 12) mice showed elevated histological and endoscopic scores compared to respective H(2)O controls (n = 9 each). However, no
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| Item type | Article | ||||
| Journal or Publication Title | Digestion | ||||
| Publisher: | KARGER | ||||
|---|---|---|---|---|---|
| Place of Publication: | BASEL | ||||
| Volume: | 84 | ||||
| Page Range: | pp. 156-167 | ||||
| Date | 2011 | ||||
| Additional Information (public) | OA-Komponente aus Allianzlizenz | ||||
| Institutions | Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin | ||||
| Identification Number |
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| Keywords | NITRIC-OXIDE; MICE; APOPTOSIS; CERAMIDE; BETA-GLUCOSIDASE-2; REGENERATION; PURIFICATION; COLONOSCOPY; DISEASE; DEATH; beta-Glucosidase; DSS colitis; Ceramide; Apoptosis; Cell regeneration | ||||
| Dewey Decimal Classification | 600 Technology > 610 Medical sciences Medicine | ||||
| Status | Published | ||||
| Refereed | Yes, this version has been refereed | ||||
| Created at the University of Regensburg | Yes | ||||
| URN of the UB Regensburg | urn:nbn:de:bvb:355-epub-409028 | ||||
| Item ID | 40902 |
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