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Knock-Out of beta-Glucosidase 2 Has No Influence on Dextran Sulfate Sodium-Induced Colitis
Scharl, M., Leucht, K., Frey-Wagner, I., Zeitz, J., Hausmann, M., Fischbeck, A., Liebisch, Gerhard
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(2011)
Knock-Out of beta-Glucosidase 2 Has No Influence on Dextran Sulfate Sodium-Induced Colitis.
Digestion 84, S. 156-167.
Veröffentlichungsdatum dieses Volltextes: 24 Okt 2019 11:48
Artikel
DOI zum Zitieren dieses Dokuments: 10.5283/epub.40902
Zusammenfassung
Background/Aims: The non-lysosomal glucosylceramidase, beta-glucosidase (Gba2), hydrolyzes glucosylceramide to glucose and ceramide (Cer). Cer is a potent second-messenger lipid that plays an important role in signaling cascades involved in apoptosis. The aim of this study was to investigate whether Gba2 knock-out (Gba2(-/-)) affects the extent of dextran sulfate sodium (DSS)-induced colitis in ...
Background/Aims: The non-lysosomal glucosylceramidase, beta-glucosidase (Gba2), hydrolyzes glucosylceramide to glucose and ceramide (Cer). Cer is a potent second-messenger lipid that plays an important role in signaling cascades involved in apoptosis. The aim of this study was to investigate whether Gba2 knock-out (Gba2(-/-)) affects the extent of dextran sulfate sodium (DSS)-induced colitis in mice. Methods: Acute colitis was induced in wild-type (WT) and Gba2(-/-) mice by administration of 2% DSS in drinking water. After 7 days, mice underwent colonoscopy and were sacrificed. Results: Both DSS-treated WT (n = 10) and Gba2(-/-) (n = 12) mice showed elevated histological and endoscopic scores compared to respective H(2)O controls (n = 9 each). However, no
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Details
| Dokumentenart | Artikel | ||||
| Titel eines Journals oder einer Zeitschrift | Digestion | ||||
| Verlag: | KARGER | ||||
|---|---|---|---|---|---|
| Ort der Veröffentlichung: | BASEL | ||||
| Band: | 84 | ||||
| Seitenbereich: | S. 156-167 | ||||
| Datum | 2011 | ||||
| Zusätzliche Informationen (Öffentlich) | OA-Komponente aus Allianzlizenz | ||||
| Institutionen | Medizin > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin | ||||
| Identifikationsnummer |
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| Stichwörter / Keywords | NITRIC-OXIDE; MICE; APOPTOSIS; CERAMIDE; BETA-GLUCOSIDASE-2; REGENERATION; PURIFICATION; COLONOSCOPY; DISEASE; DEATH; beta-Glucosidase; DSS colitis; Ceramide; Apoptosis; Cell regeneration | ||||
| Dewey-Dezimal-Klassifikation | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin | ||||
| Status | Veröffentlicht | ||||
| Begutachtet | Ja, diese Version wurde begutachtet | ||||
| An der Universität Regensburg entstanden | Ja | ||||
| URN der UB Regensburg | urn:nbn:de:bvb:355-epub-409028 | ||||
| Dokumenten-ID | 40902 |
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