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Knock-Out of beta-Glucosidase 2 Has No Influence on Dextran Sulfate Sodium-Induced Colitis

Scharl, M., Leucht, K., Frey-Wagner, I., Zeitz, J., Hausmann, M., Fischbeck, A., Liebisch, Gerhard , Schmitz, Gerd and Rogler, Gerhard (2011) Knock-Out of beta-Glucosidase 2 Has No Influence on Dextran Sulfate Sodium-Induced Colitis. Digestion 84, pp. 156-167.

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Date of publication of this fulltext: 24 Oct 2019 11:48

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Other URL: https://www.karger.com/Article/FullText/327380


Background/Aims: The non-lysosomal glucosylceramidase, β-glucosidase (Gba2), hydrolyzes glucosylceramide to glucose and ceramide (Cer). Cer is a potent second-messenger lipid that plays an important role in signaling cascades involved in apoptosis. The aim of this study was to investigate whether Gba2 knock-out (Gba2–/–) affects the extent of dextran sulfate sodium (DSS)-induced colitis in mice. ...


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Item type:Article
Additional Information (public):OA-Komponente aus Allianzlizenz
Institutions:Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin
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Keywords:Apoptosis, Cell regeneration, β-Glucosidase, DSS colitis, Ceramide
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:40902
Owner only: item control page


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