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Fifty-kDa Hyaluronic Acid Upregulates Some Epidermal Genes without Changing TNF-α Expression in Reconstituted Epidermis

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Farwick, M. ; Gauglitz, G. ; Pavicic, T. ; Köhler, T. ; Wegmann, M. ; Schwach-Abdellaoui, K. ; Malle, D. ; Tarabin, V. ; Schmitz, Gerd ; Korting, H. C.
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Date of publication of this fulltext: 06 Nov 2019 09:59


Background: Due to its strong water binding potential, hyaluronic acid (HA) is a well-known active ingredient for cosmetic applications. However, based on its varying molecular size, skin penetration of HA may be limited. Recent studies have demonstrated that low-molecular-weight HA (LMW HA) may show a certain proinflammatory activity. We thus aimed to characterize an LMW-sized HA molecule that ...


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