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Cellular localization and characterization of Cyclooxygenase-2 in interstitial cells of the kidney

Fuchs, Michaela Alexandra Anna (2019) Cellular localization and characterization of Cyclooxygenase-2 in interstitial cells of the kidney. PhD, Universität Regensburg.

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Date of publication of this fulltext: 11 Nov 2019 06:20

Abstract (English)

Cyclooxygenase 2 is a key enzyme in the production of prostaglandins. The widespread application of Cox-2 selective inhibitors to treat pain and inflammation has shown severe renal side effects for these drugs. But the exact expression sites for Cox-2 and its normal function in the kidney is not yet clear. Utilizing a novel in-situ hybridization technique Cox-2 could be distinctly located in ...

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Translation of the abstract (German)

Cyclooxygenase-2 (Cox-2) ist das Schlüsselenzym in der Produktion von Prostaglandinen. Die weitreichende Anwendung von Cox-2 selektiven Inhibitoren zur Behandlung von Schmerzen und Entzündungen hat schwere renale Nebenwirkungen aufgezeigt. Jedoch sind die genauen Expressionsorte für Cox-2 und deren basale Funktion in der Niere noch nicht eindeutig geklärt. Unter Verwendung einer neuen Methode ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:11 November 2019
Referee:Prof. Dr. Armin Kurtz
Date of exam:17 October 2019
Institutions:Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Armin Kurtz
Keywords:Cyclooxygenase, Niere, interstitielle Zellen
Dewey Decimal Classification:500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:41001
Owner only: item control page

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