A Small Number of HER2 Redirected CAR T Cells Significantly Improves Immune Response of Adoptively Transferred Mouse Lymphocytes against Human Breast Cancer Xenografts

URN to cite this document:: urn:nbn:de:bvb:355-epub-415179
DOI to cite this document:: 10.5283/epub.41517

Tóth, G. ; Szöllősi, J. ; Abken, Hinrich

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Date of publication of this fulltext: 07 Feb 2020 09:13

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Abstract

HER2 positive JIMT-1 breast tumors are resistant to trastuzumab treatment in vitro and develop resistance to trastuzumab in vivo in SCID mice. We explored whether these resistant tumors could still be eliminated by T cells redirected by a second-generation chimeric antigen receptor (CAR) containing a CD28 costimulatory domain and targeting HER2 with a trastuzumab-derived scFv. In vitro, T cells ...