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Augmenter of Liver Regeneration Reduces Ischemia Reperfusion Injury by Less Chemokine Expression, Gr-1 Infiltration and Oxidative Stress

URN to cite this document:
urn:nbn:de:bvb:355-epub-415250
Weiss, Thomas S. ; Lupke, Madeleine ; Dayoub, Rania ; Geissler, Edward K. ; Schlitt, Hans J. ; Melter, Michael ; Eggenhofer, Elke
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Date of publication of this fulltext: 07 Feb 2020 11:37


Abstract

Hepatic ischemia reperfusion injury (IRI) is a major complication in liver resection and transplantation. Here, we analyzed the impact of recombinant human augmenter of liver regeneration (rALR), an anti-oxidative and anti-apoptotic protein, on the deleterious process induced by ischemia reperfusion (IR). Application of rALR reduced tissue damage (necrosis), levels of lipid peroxidation ...

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