Augmenter of Liver Regeneration Reduces Ischemia Reperfusion Injury by Less Chemokine Expression, Gr-1 Infiltration and Oxidative Stress

URN to cite this document:: urn:nbn:de:bvb:355-epub-415250
DOI to cite this document:: 10.5283/epub.41525

Weiss, Thomas S.

; Lupke, Madeleine ; Dayoub, Rania

; Geissler, Edward K. ; Schlitt, Hans J. ; Melter, Michael ; Eggenhofer, Elke

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Date of publication of this fulltext: 07 Feb 2020 11:37

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Abstract

Hepatic ischemia reperfusion injury (IRI) is a major complication in liver resection and transplantation. Here, we analyzed the impact of recombinant human augmenter of liver regeneration (rALR), an anti-oxidative and anti-apoptotic protein, on the deleterious process induced by ischemia reperfusion (IR). Application of rALR reduced tissue damage (necrosis), levels of lipid peroxidation ...