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The role of mechanotransduction versus hypoxia during simulated orthodontic compressive strain—an in vitro study of human periodontal ligament fibroblasts

URN to cite this document:
urn:nbn:de:bvb:355-epub-415295
Ullrich, Niklas ; Schröder, Agnes ; Jantsch, Jonathan ; Spanier, Gerrit ; Proff, Peter ; Kirschneck, Christian
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Date of publication of this fulltext: 07 Feb 2020 13:00


Abstract

During orthodontic tooth movement (OTM) mechanical forces trigger pseudo-inflammatory, osteoclastogenic and remodelling processes in the periodontal ligament (PDL) that are mediated by PDL fibroblasts via the expression of various signalling molecules. Thus far, it is unknown whether these processes are mainly induced by mechanical cellular deformation (mechanotransduction) or by concomitant ...

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