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Norepinephrine Inhibits Synovial Adipose Stem Cell Chondrogenesis via α2a-Adrenoceptor-Mediated ERK1/2 Activation

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DOI to cite this document:
El Bagdadi, K. ; Zaucke, F. ; Meurer, Andrea ; Straub, Rainer H. ; Jenei-Lanzl, Z.
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 10 Feb 2020 09:17


In recent years, first evidences emerged that sympathetic neurotransmitters influence osteoarthritis (OA) manifestation. Joint-resident stem cells might contribute to cartilage repair, however, their chondrogenic function is reduced. The neurotransmitter norepinephrine (NE) was detected in the synovial fluid of trauma and OA patients. Therefore, the aim of this study was to analyse how NE ...


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