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mRNA-Expression of KRT5 and KRT20 Defines Distinct Prognostic Subgroups of Muscle-Invasive Urothelial Bladder Cancer Correlating with Histological Variants

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Eckstein, M. ; Wirtz, R. M. ; Gross-Weege, M. ; Breyer, Johannes ; Burger, Maximilian ; ; ; ; ; ; ; ; ; ;
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 10 Feb 2020 15:09


Recently, muscle-invasive bladder cancer (MIBC) has been subclassified by gene expression profiling, with a substantial impact on therapy response and patient outcome. We tested whether these complex molecular subtypes of MIBC can be determined by mRNA detection of keratin 5 (KRT5) and keratin 20 (KRT20). Reverse transcriptase quantitative polymerase chain reaction (RT-qPCR) was applied to ...


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