NAD(P)H:quinone oxidoreductase 1 (NQO1) P187S polymorphism and prostate cancer risk in Caucasians

URN to cite this document:: urn:nbn:de:bvb:355-epub-415592
DOI to cite this document:: 10.5283/epub.41559

Stoehr, Christine G. ; Nolte, Elke ; Wach, Sven ; Wieland, Wolf F. ; Hofstädter, Ferdinand

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Date of publication of this fulltext: 12 Feb 2020 10:14

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Abstract

NAD(P)H:quinone oxidoreductase 1 (NQO1) catalyses the reduction of quinoid compounds to hydroquinones, preventing the generation of free radicals and reactive oxygen. A “C” to “T” transversion at position 609 of NQO1, leading to a nonsynonymous amino acid change (Pro187Ser, P187S), results in an altered enzyme activity. No NQO1 protein activity was detected in NQO1 609TT genotype, and low to ...