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NAD(P)H:quinone oxidoreductase 1 (NQO1) P187S polymorphism and prostate cancer risk in Caucasians

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Stoehr, Christine G. ; Nolte, Elke ; Wach, Sven ; Wieland, Wolf F. ; Hofstädter, Ferdinand
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 12 Feb 2020 10:14


NAD(P)H:quinone oxidoreductase 1 (NQO1) catalyses the reduction of quinoid compounds to hydroquinones, preventing the generation of free radicals and reactive oxygen. A “C” to “T” transversion at position 609 of NQO1, leading to a nonsynonymous amino acid change (Pro187Ser, P187S), results in an altered enzyme activity. No NQO1 protein activity was detected in NQO1 609TT genotype, and low to ...


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