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Novel selective butyrylcholinesterase inhibitors incorporating antioxidant functionalities as potential bimodal therapeutics for Alzheimer’s Disease

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Jones, Mike ; Wang, Jun ; Harmon, S. ; Kling, Beata ; Heilmann, Jörg
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 12 Feb 2020 13:00


Isosorbide-2-carbamates-5-aryl esters are highly potent and very selective butyrylcholinesterase inhibitors. The objective of the present work was to address the hypothesis that the isosorbide-aryl-5-ester group could be replaced with an antioxidant functionality while maintaining inhibitor effects and selectivity. We successfully incorporated ferulic acid or lipoic acid groups producing potent ...


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