Novel selective butyrylcholinesterase inhibitors incorporating antioxidant functionalities as potential bimodal therapeutics for Alzheimer’s Disease

URN to cite this document:: urn:nbn:de:bvb:355-epub-415653
DOI to cite this document:: 10.5283/epub.41565

Jones, Mike ; Wang, Jun ; Harmon, S. ; Kling, Beata ; Heilmann, Jörg

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Date of publication of this fulltext: 12 Feb 2020 13:00

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Abstract

Isosorbide-2-carbamates-5-aryl esters are highly potent and very selective butyrylcholinesterase inhibitors. The objective of the present work was to address the hypothesis that the isosorbide-aryl-5-ester group could be replaced with an antioxidant functionality while maintaining inhibitor effects and selectivity. We successfully incorporated ferulic acid or lipoic acid groups producing potent ...