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Plasma next generation sequencing and droplet digital-qPCR-based quantification of circulating cell-free RNA for noninvasive early detection of cancer

URN to cite this document:
urn:nbn:de:bvb:355-epub-415691
DOI to cite this document:
10.5283/epub.41569
Metzenmacher, M. ; Váraljai, R. ; Hegedüs, B. ; Klein, Christoph A. ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
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Date of publication of this fulltext: 12 Feb 2020 15:12


Abstract

Early detection of cancer holds high promise for reducing cancer-related mortality. Detection of circulating tumor-specific nucleic acids holds promise, but sensitivity and specificity issues remain with current technology. We studied cell-free RNA (cfRNA) in patients with non-small cell lung cancer (NSCLC; n = 56 stage IV, n = 39 stages I-III), pancreatic cancer (PDAC, n = 20 stage III), ...

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