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TMEM16F/Anoctamin 6 in Ferroptotic Cell Death

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Ousingsawat, Jiraporn ; Schreiber, Rainer ; Kunzelmann, Karl
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 13 Feb 2020 10:12


Ca2+ activated Cl- channels (TMEM16A; ANO1) support cell proliferation and cancer growth. Expression of TMEM16A is strongly enhanced in different types of malignomas. In contrast, TMEM16F (ANO6) operates as a Ca2+ activated chloride/nonselective ion channel and scrambles membrane phospholipids to expose phosphatidylserine at the cell surface. Both phospholipid scrambling and cell swelling induced ...


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