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Combined treatment with MEK and mTOR inhibitors is effective in vitro and in vivo models of hepatocellular carcinoma

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Liu, Xianqiong ; Hu, Junjie ; Song, Xinhua ; Utpatel, Kirsten ; Evert, Matthias ; Calvisi, Diego F.
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 13 Feb 2020 10:35


Background: Hepatocellular carcinoma (HCC) is the most common primary liver cancer histotype, characterized by high biological aggressiveness and scarce treatment options. Recently, we have established a clinically relevant murine HCC model by co-expressing activated forms of v-akt murine thymoma viral oncogene homolog (AKT) and oncogene c-mesenchymal-epithelial transition (c-Met) proto-oncogenes ...


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