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Norrin protects retinal ganglion cells from excitotoxic damage via the induction of LIF

URN to cite this document:
urn:nbn:de:bvb:355-epub-415819
DOI to cite this document:
10.5283/epub.41581
Kassumeh, S. ; Leopold, Stephanie Anna ; Fuchshofer, Rudolf ; Tamm, Ernst R. ; Ohlmann, Andreas
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License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 13 Feb 2020 10:54


Abstract

Purpose: To investigate whether and how leukemia inhibitory factor (Lif) is involved in mediating the neuroprotective effects of Norrin on retinal ganglion cells (RGC) following excitotoxic damage. Norrin is a secreted protein that protects RGC from N-methyl-d-aspartate (NMDA)-mediated excitotoxic damage, which is accompanied by increased expression of protective factors such as Lif, Edn2 and ...

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