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Lack of a retinal phenotype in a Syne-2/Nesprin-2 knockout mouse model

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Falk, Nathalie ; Joachimsthaler, A. ; Kessler, K.
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 20 Feb 2020 09:38


Syne-2 (also known as Nesprin-2) is a member of a family of proteins that are found primarily in the outer nuclear membrane, as well as other subcellular compartments. Syne-2 contains a C-terminal KASH transmembrane domain and is part of a protein network that associates the nuclear envelope to the cytoskeleton via the binding to actin filaments. Syne-2 plays a role in nuclear migration, nuclear ...


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