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iPla2β Deficiency Suppresses Hepatic ER UPR, Fxr, and Phospholipids in Mice fed with MCD Diet Resulting in Exacerbated Hepatic Bile Acids and Biliary Cell Proliferation

URN to cite this document:
urn:nbn:de:bvb:355-epub-415872
Ming, Yanan ; Zhu, Xingya ; Tuma-Kellner, S. ; Ganzha, Alexandra ; Liebisch, Gerhard
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Date of publication of this fulltext: 13 Feb 2020 12:52


Abstract

Background: Group VIA calcium-independent phospholipase A2 (iPla2β) regulates homeostasis and remodeling of phospholipids (PL). We previously showed that iPla2β−/− mice fed with a methionine-choline-deficient diet (MCD) exhibited exaggerated liver fibrosis. As iPla2β is located in the endoplasmic reticulum (ER), we investigated the mechanisms for this by focusing on hepatic ER unfolded protein ...

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