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Inhibition of MELK Protooncogene as an Innovative Treatment for Intrahepatic Cholangiocarcinoma

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Cigliano, Antonio ; Pilo, M. G. ; Mela, M. ; Evert, Matthias ; Calvisi, Diego F. ; Utpatel, Kirsten
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 13 Feb 2020 13:52


Background and Objectives: Intrahepatic cholangiocarcinoma (iCCA) is a pernicious tumor characterized by a dismal outcome and scarce therapeutic options. To substantially improve the prognosis of iCCA patients, a better understanding of the molecular mechanisms responsible for development and progression of this disease is imperative. In the present study, we aimed at elucidating the role of the ...


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