Diffusion-weighted imaging in oral squamous cell carcinoma using 3 Tesla MRI: is there a chance for preoperative discrimination between benign and malignant lymph nodes in daily clinical routine?

URN to cite this document:

urn:nbn:de:bvb:355-epub-417329 Copy

DOI to cite this document:

10.5283/epub.41732 Copy

Wendl, Christina M. ; Müller, Steffen ; Eiglsperger, Johannes ; Fellner, Claudia ; Jung, Ernst Michael ; Meier, Johannes K.

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Date of publication of this fulltext: 02 Mar 2020 14:59

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Item type:	Article
Journal or Publication Title:	Acta Radiologica
Publisher:	SAGE PUBLICATIONS LTD
Place of Publication:	LONDON
Volume:	57
Page Range:	pp. 939-946
Date:	2016
Additional Information (public):	Open Access-Komponente aus einer Allianzlizenz
Institutions:	Medicine > Lehrstuhl für Röntgendiagnostik Medicine > Lehrstuhl für Röntgendiagnostik
Identification Number:	Value Type 10.1177/0284185115609365 DOI
Keywords:	COMPUTED-TOMOGRAPHY; NECK DISSECTION; DIAGNOSTIC-ACCURACY; HEAD; VOLUME; CANCER; DIFFERENTIATION; COEFFICIENT; RATIONALE; Oral squamous cell carcinoma; lymph nodes; diffusion-weighted imaging (DWI); apparent diffusion coefficient; magnetic resonance imaging (MRI)
Dewey Decimal Classification:	600 Technology > 610 Medical sciences Medicine
Status:	Published
Refereed:	Yes, this version has been refereed
Created at the University of Regensburg:	Yes
Item ID:	41732

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Abstract

Background Preoperative staging of cervical lymph nodes is important to determine the extent of neck dissection in patients with oral squamous cell carcinoma (OSCC). Purpose To evaluate whether a preoperative discrimination of benign and malignant cervical lymph nodes with diffusion-weighted imaging (DWI) (3T) is feasible for clinical application. Material and Methods Forty-five patients with ...

Abstract

Background Preoperative staging of cervical lymph nodes is important to determine the extent of neck dissection in patients with oral squamous cell carcinoma (OSCC). Purpose To evaluate whether a preoperative discrimination of benign and malignant cervical lymph nodes with diffusion-weighted imaging (DWI) (3T) is feasible for clinical application. Material and Methods Forty-five patients with histological proven OSCC underwent preoperative 3T-MRI. DWI (b=0, 500, and 1000s/mm(2)) was added to the standard magnetic resonance imaging (MRI) protocol. Mean apparent diffusion coefficients (ADC(mean)) were measured for lymph nodes with 3mm or more in short axis by two independent readers. Finally, these results were matched with histology. Results Mean ADC was significantly higher for malignant than for benign nodes (1.1430.188 * 10(-3) mm(2)/s vs. 0.987 +/- 0.215 * 10(-3) mm(2)/s). Using an ADC value of 0.994 * 10(-3) mm(2)/s as threshold results in a sensitivity of 80%, specificity of 65%, positive predictive value of 31%, and negative predictive value of 93%. Conclusion Due to a limited sensitivity and specificity DWI alone is not suitable to reliably discriminate benign from malignant cervical lymph nodes in daily clinical routine. Hence, the preoperative determination of the extent of neck dissection on the basis of ADC measurements is not meaningful.

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Metadata last modified: 25 Nov 2020 15:51

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