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Surfactant proteins in pediatric interstitial lung disease

Griese, Matthias ; Lorenz, Elke ; Hengst, Meike ; Schams, Andrea ; Wesselak, Traudl ; Rauch, Daniela ; Wittmann, Thomas ; Kirchberger, Valerie ; Escribano, Amparo ; Schaible, Thomas ; Baden, Winfried ; Schulze, Johannes ; Krude, Heiko ; Aslanidis, Charalampos ; Schwerk, Nicolaus ; Kappler, Matthias ; Hartl, Dominik ; Lohse, Peter ; Zarbock, Ralf


BACKGROUND: Children's interstitial lung diseases (chlLD) comprise a broad spectrum of diseases. Besides the genetically defined surfactant dysfunction disorders, most entities pathologically involve the alveolar surfactant region, possibly affecting the surfactant proteins SP-B and SP-C. Therefore, our objective was to determine the value of quantitation of SP-B and SP-C levels in ...


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