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The second window of desflurane-induced preconditioning is mediated by STAT3: role of Pim-1 kinase

Stumpner, J. ; Tischer-Zeitz, T. ; Lotz, C. ; Umminger, J. ; Neuwirth, A. ; Smul, T. M. ; Redel, A. ; Kehl, F. ; Roewer, N. ; Lange, M.


Background: Late ischemic preconditioning is mediated via nuclear transcription factor signal transducer and activator of transcription 3 (STAT3). Pim-1 kinase reduces infarct size in cardiomyocytes and is regulated by STAT3. We tested the hypothesis that late desflurane-induced preconditioning (DES-SWOP) is mediated via STAT3 and Pim-1. Methods: After institutional approval, ...


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