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Soluble TL1A is sufficient for activation of death receptor 3

Bittner, Sebastian ; Knoll, Gertrud ; Füllsack, Simone ; Kurz, Maria ; Wajant, Harald ; Ehrenschwender, Martin


Death receptor 3 (DR3) is a typical member of the tumor necrosis factor receptor family, and was initially identified as a T-cell co-stimulatory molecule. However, further studies revealed a more complex and partly dichotomous role for DR3 and its ligand TL1A under (patho) physiological conditions. TL1A and DR3 are not only a driving force in the development of autoimmune and inflammatory ...


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