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The impact of cationic substituents in phenalen-1-one photosensitizers on antimicrobial photodynamic efficacy

Tabenski, Isabelle ; Cieplik, Fabian ; Tabenski, Laura ; Regensburger, Johannes ; Hiller, Karl-Anton ; Buchalla, Wolfgang ; Maisch, Tim ; Späth, Andreas


Light-mediated killing of pathogens by cationic photosensitizers (PS) is a promising antimicrobial approach avoiding resistance as being present upon the use of antibiotics. In this study we focused on the impact of the substituents in phenalen-1-one PS. Photodynamic efficacy depending on positively charged moieties including a primary aliphatic, quaternary aliphatic, aromatic ammonium and a ...


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