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Atopic dermatitis is associated with an increased risk for rheumatoid arthritis and inflammatory bowel disease, and a decreased risk for type 1 diabetes

Schmitt, Jochen ; Schwarz, Kristin ; Baurecht, Hansjörg ; Hotze, Melanie ; Fölster-Holst, Regina ; Rodríguez, Elke ; Lee, Young A. E. ; Franke, Andre ; Degenhardt, Frauke ; Lieb, Wolfgang ; Gieger, Christian ; Kabesch, Michael ; Nöthen, Markus M. ; Irvine, Alan D. ; McLean, W. H. Irwin ; Deckert, Stefanie ; Stephan, Victoria ; Schwarz, Peter ; Aringer, Martin ; Novak, Natalija ; Weidinger, Stephan



Abstract

Background: Atopic dermatitis (AD) is characterized by epidermal barrier failure and immune-mediated inflammation. Evidence on AD as a potential risk factor for inflammatory comorbidities is scarce. Objectives: We sought to test the hypothesis that prevalent AD is a risk factor for incident rheumatoid arthritis (RA) and inflammatory bowel disease (IBD; Crohn disease [CD], ulcerative colitis [UC]) ...

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