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RORγt+ IL-22-producing NKp46+ cells protect from hepatic ischemia reperfusion injury in mice

Eggenhofer, Elke ; Sabet-Rashedi, Manije ; Lantow, Margareta ; Renner, Philipp ; Rovira, Jordi ; Koehl, Gudrun E. ; Schlitt, Hans J. ; Geissler, Edward K. ; Kroemer, Alexander



Abstract

Background & Aims: NKp46(+) cells are major effector cells in the pathogenesis of hepatic ischemia reperfusion injury (IRI). Nevertheless, the precise role of unconventional subsets like the IL-22-producing NKp46(+) cells (NK22) remains unknown. The purpose of this study was to examine the role of NK22 cells in IRI in transplantation, particularly with respect to regulation by the transcription ...

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