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Epicardial adipocyte hypertrophy: Association with M1-polarization and toll-like receptor pathways in coronary artery disease patients

Vianello, E. ; Dozio, E. ; Arnaboldi, F. ; Marazzi, M.G. ; Martinelli, C. ; Lamont, J. ; Tacchini, L. ; Sigrüner, A. ; Schmitz, G. ; Corsi Romanelli, M.M.



Abstract

Background and aims: In coronary artery disease (CAD) epicardial adipose tissue (EAT) shows an elevated inflammatory infiltrate. Toll-like receptors (TLRs) are important mediators of adipose tissue inflammation and they are able to recognize endogenous products released by damaged cells. Because adipocyte death may be driven by hypertrophy, our aim was to investigate in CAD and non-CAD patients ...

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