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Structural and functional insights into the fly microRNA biogenesis factor Loquacious

Jakob, Leonhard ; Treiber, Thomas ; Treiber, Nora ; Gust, Alexander ; Kramm, Kevin ; Hansen, Kerrin ; Stotz, Mathias ; Wankerl, Ludwig ; Herzog, Franz ; Hannus, Stefan ; Grohmann, Dina ; Meister, Gunter



Abstract

In the microRNA (miRNA) pathway, Dicer processes precursors to mature miRNAs. For efficient processing, double-stranded RNA-binding proteins support Dicer proteins. In flies, Loquacious (Logs) interacts with Dicer1 (dmDcr1) to facilitate miRNA processing. Here, we have solved the structure of the third double-stranded RNA-binding domain (dsRBD) of Logs and define specific structural elements that ...

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