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Allogeneic Stem Cell Transplantation Improves Survival in Patients with Acute Myeloid Leukemia Characterized by a High Allelic Ratio of Mutant FLT3-ITD

Ho, Anthony D. ; Schetelig, Johannes ; Bochtler, Tilmann ; Schaich, Markus ; Schäfer-Eckart, Kerstin ; Hänel, Mathias ; Rösler, Wolf ; Einsele, Hermann ; Kaufmann, Martin ; Serve, Hubert ; Berdel, Wolfgang E. ; Stelljes, Matthias ; Mayer, Jiri ; Reichle, Albrecht ; Baldus, Claudia D. ; Schmitz, Norbert ; Kramer, Michael ; Röllig, Christoph ; Bornhäuser, Martin ; Thiede, Christian ; Ehninger, Gerhard



Abstract

Allogeneic hematopoietic cell transplantation (alloHCT) as a postremission therapy in patients with FLT3-ITD-positive intermediate-risk acute myeloid leukemia (AML) remains controversial. FLT3-ITD mutations are heterogeneous with respect to allelic ratio, location, and length of the insertion, with a high mutant-to-wild type ratio consistently associated with inferior prognosis. We ...

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