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Serine 220 phosphorylation of the Merkel cell polyomavirus large T antigen crucially supports growth of Merkel cell carcinoma cells

Schrama, David ; Hesbacher, Sonja ; Angermeyer, Sabrina ; Schlosser, Andreas ; Haferkamp, Sebastian ; Aue, Annemarie ; Adam, Christian ; Weber, Alexandra ; Schmidt, Marc ; Houben, Roland



Abstract

Merkel cell polyomavirus (MCPyV) is regarded as a major causal factor for Merkel cell carcinoma (MCC). Indeed, tumor cell growth of MCPyV-positive MCC cells is dependent on the expression of a truncated viral Large T antigen (LT) with an intact retinoblastoma protein (RB)-binding site. Here we determined the phosphorylation pattern of a truncated MCPyV-LT characteristically for MCC by mass ...

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