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Patient-individualized CD8+ cytolytic T-cell therapy effectively combats minimal residual leukemia in immunodeficient mice

Distler, Eva ; Albrecht, Jana ; Brunk, Ariane ; Khan, Shamsul ; Schnürer, Elke ; Frey, Michaela ; Mottok, Anja ; Jordán-Garrote, Ana-Laura ; Brede, Christian ; Beilhack, Andreas ; Mades, Andreas ; Tomsitz, Dirk ; Theobald, Matthias ; Herr, Wolfgang ; Hartwig, Udo F.


Adoptive transfer of donor-derived cytolytic T-lymphocytes (CTL) has evolved as a promising strategy to improve graft-versus-leukemia (GvL) effects in allogeneic hematopoietic stem-cell transplantation. However, durable clinical responses are often hampered by limited capability of transferred T cells to establish effective and sustained antitumor immunity in vivo. We therefore analyzed GvL ...


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