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Control of glioma cell migration and invasiveness by GDF-15

Codó, Paula ; Weller, Michael ; Kaulich, Kerstin ; Schraivogel, Daniel ; Silginer, Manuela ; Reifenberger, Guido ; Meister, Gunter ; Roth, Patrick



Abstract

Growth and differentiation factor (GDF)-15 is a member of the transforming growth factor (TGF)-beta family of proteins. GDF-15 levels are increased in the blood and cerebrospinal fluid of glioblastoma patients. Using a TCGA database interrogation, we demonstrate that high GDF-15 expression levels are associated with poor survival of glioblastoma patients. To elucidate the role of GDF-15 in ...

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