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Co-activation of AKT and c-Met triggers rapid hepatocellular carcinoma development via the mTORC1/FASN pathway in mice

Hu, Junjie ; Che, Li ; Li, Lei ; Pilo, Maria G. ; Cigliano, Antonio ; Ribback, Silvia ; Li, Xiaolei ; Latte, Gavinella ; Mela, Marta ; Evert, Matthias ; Dombrowski, Frank ; Zheng, Guohua ; Chen, Xin ; Calvisi, Diego F.


Activation of the AKT/mTOR cascade and overexpression of c-Met have been implicated in the development of human hepatocellular carcinoma (HCC). To elucidate the functional crosstalk between the two pathways, we generated a model characterized by the combined expression of activated AKT and c-Met in the mouse liver. Co-expression of AKT and c-Met triggered rapid liver tumor development and mice ...


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