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Impairing autophagy in retinal pigment epithelium leads to inflammasome activation and enhanced macrophage-mediated angiogenesis

Liu, Jian ; Copland, David A. ; Theodoropoulou, Sofia ; Chiu, Hsi An Amy ; Barba, Miriam Durazo ; Mak, Ka Wang ; Mack, Matthias ; Nicholson, Lindsay B. ; Dick, Andrew D.



Abstract

Age-related decreases in autophagy contribute to the progression of age-related macular degeneration (AMD). We have now studied the interaction between autophagy impaired in retinal pigment epithelium (RPE) and the responses of macrophages. We find that dying RPE cells can activate the macrophage inflammasome and promote angiogenesis. In vitro, inhibiting rotenone-induced autophagy in RPE cells ...

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