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Causal Assessment of Serum Urate Levels in Cardiometabolic Diseases Through a Mendelian Randomization Study

Keenan, Tanya ; Zhao, Wei ; Rasheed, Asif ; Ho, Weang K. ; Malik, Rainer ; Felix, Janine F. ; Young, Robin ; Shah, Nabi ; Samuel, Maria ; Sheikh, Nasir ; Mucksavage, Megan L. ; Shah, Omar ; Li, Jin ; Morley, Michael ; Laser, Annika ; Mallick, Nadeem Hayat ; Zaman, Khan Shah ; Ishaq, Mohammad ; Rasheed, Syed Zahed ; Memon, Fazal-ur-Rehman ; Ahmed, Faisal ; Hanif, Bashir ; Lakhani, Muhammad Shakir ; Fahim, Muhammad ; Ishaq, Madiha ; Shardha, Naresh Kumar ; Ahmed, Naveeduddin ; Mahmood, Khalid ; Iqbal, Waseem ; Akhtar, Saba ; Raheel, Rabia ; O'Donnell, Christopher J. ; Hengstenberg, Christian ; März, Winifred ; Kathiresan, Sekar ; Samani, Nilesh ; Goel, Anuj ; Hopewell, Jemma C. ; Chambers, John ; Cheng, Yu-Ching ; Sharma, Pankaj ; Yang, Qiong ; Rosand, Jonathan ; Boncoraglio, Giorgio B. ; Kazmi, Shahana Urooj ; Hakonarson, Hakon ; Köttgen, Anna ; Kalogeropoulos, Andreas ; Frossard, Philippe ; Kamal, Ayeesha ; Dichgans, Martin ; Cappola, Thomas ; Reilly, Muredach P. ; Danesh, John ; Rader, Daniel J. ; Voight, Benjamin F. ; Saleheen, Danish



Abstract

BACKGROUND Although epidemiological studies have reported positive associations between circulating urate levels and cardiometabolic diseases, causality remains uncertain. OBJECTIVES Through a Mendelian randomization approach, we assessed whether serum urate levels are causally relevant in type 2 diabetes mellitus (T2DM), coronary heart disease (CHD), ischemic stroke, and heart failure (HF). ...

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