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BRAF and RAS Mutations in Sporadic and Secondary Pyogenic Granuloma

Groesser, Leopold ; Peterhof, Eva ; Evert, Matthias ; Landthaler, Michael ; Berneburg, Mark ; Hafner, Christian


Pyogenic granuloma (PG) is a common benign vascular skin lesion presenting as a rapidly growing angiomatous papule. The pathogenesis of most sporadic PGs and PGs associated with port wine stains (PWSs) remains elusive. We report that of 10 PGs secondarily arisen on a PWS, 8 showed a BRAF c.1799T>A (p.(Val600Glu)) and 1 a NRAS c.182A>G (p.(Gln61Arg)) mutation. The GNAQ c.548G>A mutation was ...


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