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Secreted frizzled-related protein 4 predicts progression of autosomal dominant polycystic kidney disease

Zschiedrich, Stefan ; Budde, Klemens ; Nürnberger, Jens ; Wanner, Christoph ; Sommerer, Claudia ; Kunzendorf, Ulrich ; Banas, Bernhard ; Hoerl, Walter H. ; Obermüller, Nicholas ; Arns, Wolfgang ; Pavenstädt, Hermann ; Gaedeke, Jens ; Lindner, Tom H. ; Faerber, Lothar ; Wimmer, Peter ; Stork, Roland ; Eckardt, Kai-Uwe ; Walz, Gerd



Abstract

Autosomal dominant polycystic kidney disease (ADPKD) is a common autosomal dominant condition associated with renal cysts and development of renal failure. With the availability of potential therapies, one major obstacle remains the lack of readily available parameters that identify patients at risk for disease progression and/or determine the efficacy of therapeutic interventions within short ...

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