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IL-10 from marginal zone precursor B cells controls the differentiation of Th17, Tfh and Tfr cells in transplantation tolerance

Lal, Girdhari ; Kulkarni, Neeraja ; Nakayama, Yumi ; Singh, Amit K. ; Sethi, Apoorva ; Burrell, Bryna E. ; Brinkman, C. Colin ; Iwami, Daiki ; Zhang, Tianshu ; Hehlgans, Thomas ; Bromberg, Jonathan S.



Abstract

B cells are known to control CD4T cell differentiation in secondary lymphoid tissues. We hypothesized that IL-10 expression by marginal zone precursor (MZP) regulatory B cells controls the differentiation and positioning of effector and regulatory T cells during tolerization. Costimulatory blockade with donor specific transfusion (DST) and anti-CD4OL mAb in C57BL/6 mice induced tolerance to ...

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