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Effects of renal denervation on renal pelvic contractions and connexin expression in rats

Koenen, A. ; Steinbach, A. ; Schaper, K. ; Zimmermann, U. ; Miehe, B. ; Kurt, B. ; Rettig, R. ; Grisk, O.



Abstract

Aims: The renal pelvis shows spontaneous rhythmic contractile activity. We assessed to what extent this activity depends on renal innervation and studied the role of connexins in pelvic contractions. Methods: Rats underwent unilateral renal denervation or renal transplantation. Renal pelvic pressure and diuresis were measured in vivo. Spontaneous and agonist-induced contractions of isolated renal ...

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