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miR-155 targets Caspase-3 mRNA in activated macrophages

De Santis, Rebecca ; Liepelt, Anke ; Mossanen, Jana C. ; Dueck, Anne ; Simons, Nadine ; Mohs, Antje ; Trautwein, Christian ; Meister, Gunter ; Marx, Gernot ; Ostareck-Lederer, Antje ; Ostareck, Dirk H.



Abstract

To secure the functionality of activated macrophages in the innate immune response, efficient life span control is required. Recognition of bacterial lipopolysaccharides (LPS) by toll-like receptor 4 (TLR4) induces downstream signaling pathways, which merge to induce the expression of cytokine genes and anti-apoptotic genes. MicroRNAs (miRNAs) have emerged as important inflammatory response ...

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