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Macrophage-derived nitric oxide initiates T-cell diapedesis and tumor rejection

Sektioglu, Ibrahim M. ; Carretero, Rafael ; Bender, Noemi ; Bogdan, Christian ; Garbi, Natalio ; Umansky, Viktor ; Umansky, Ludmila ; Urban, Katharina ; von Knebel-Döberitz, Magnus ; Somasundaram, Veena ; Wink, David ; Beckhove, Philipp ; Hämmerling, Günter J.


In tumor biology, nitric oxide (NO) is generally regarded as an immunosuppressive molecule that impedes T-cell functions and activation of endothelial cells. Contrasting with this view, we here describe a critical role for NO derived from inducible nitric oxide (iNOS)-expressing tumor macrophages in T-cell infiltration and tumor rejection as shown by iNOS gene deletion, inhibition of iNOS, or NO ...


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