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KRAS, HRAS and EGFR Mutations in Sporadic Sebaceous Gland Hyperplasia

Groesser, L ; Singer, S ; Peterhof, E ; Landthaler, M ; Heigl, U ; Schneider-Brachert, W ; Berneburg, M ; Hafner, C


Sporadic sebaceous gland hyperplasia (SGH) is a benign skin lesion, with a high prevalence in the general population. Although SGH has been attributed to both extrinsic and intrinsic factors, the underlying genetic changes have not yet been characterized. Recently, HRAS and KRAS mutations have been identified in sebaceous naevus, a hamartoma sharing histological characteristics with SGH. ...


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