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Which melanoma patient carries a BRAF-mutation? A comparison of predictive models

Eigentler, Thomas ; Assi, Zeinab ; Hassel, Jessica C. ; Heinzerling, Lucie ; Starz, Hans ; Berneburg, Mark ; Bauer, Jürgen ; Garbe, Claus



Abstract

Background: In patients with advanced melanoma the detection of BRAF mutations is considered mandatory before the initiation of an expensive treatment with BRAF/MEK inhibitors. Sometimes it is difficult to perform such an analysis if archival tumor tissue is not available and fresh tissue has to be collected. Results: 514 of 1170 patients (44%) carried a BRAF mutation. All models revealed age and ...

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