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The Human Antimicrobial Protein Bactericidal/Permeability-Increasing Protein (BPI) Inhibits the Infectivity of Influenza A Virus

Pöhlmann, Stefan ; Pinkenburg, Olaf ; Meyer, Torben ; Bannert, Norbert ; Norley, Steven ; Bolte, Kathrin ; Czudai-Matwich, Volker ; Herold, Susanne ; Gessner, André ; Schnare, Markus



Abstract

In addition to their well-known antibacterial activity some antimicrobial peptides and proteins (AMPs) display also antiviral effects. A 27 aa peptide from the N-terminal part of human bactericidal/permeability-increasing protein (BPI) previously shown to harbour antibacterial activity inhibits the infectivity of multiple Influenza A virus strains (H1N1, H3N2 and H5N1) the causing agent of the ...

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