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Transcriptional Regulation and Macrophage Differentiation

Hume, David A. ; Summers, Kim M. ; Rehli, Michael



Abstract

Monocytes and macrophages are professional phagocytes that occupy specific niches in every tissue of the body. Their survival, proliferation, and differentiation are controlled by signals from the macrophage colony-stimulating factor receptor (CSF-1R) and its two ligands, CSF-1 and interleukin-34. In this review, we address the developmental and transcriptional relationships between hematopoietic ...

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