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Long-term follow-up of five yr shows superior renal function with everolimus plus early calcineurin inhibitor withdrawal in the PROTECT randomized liver transplantation study

Sterneck, Martina ; Kaiser, Gernot M. ; Heyne, Nils ; Richter, Nicolas ; Rauchfuss, Falk ; Pascher, Andreas ; Schemmer, Peter ; Fischer, Lutz ; Klein, Christian G. ; Nadalin, Silvio ; Lehner, Frank ; Settmacher, Utz ; Gotthardt, Daniel ; Loss, Martin ; Ladenburger, Stephan ; Wimmer, Peter ; Dworak, Markus ; Schlitt, Hans J.



Zusammenfassung

Background: The 12-month (M) PROTECT study showed that de novo liver transplant recipients (LTxR) who switched from a calcineurin inhibitor (CNI)-based immunosuppression to a CNI-free everolimus (EVR)-based regimen showed numerically better renal function. Here, we present the five-yr follow-up data. Methods: PROTECT was a randomized controlled study in which LTxR received basiliximab and ...

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